The trouble with Ostarine: Jimmy Wallhead’s
16th March 2018
The World Anti-Doping Agency (WADA) publishes revised versions of five Technical Documents (TDs) (along with their Summaries of Modifications); as well as, two new Technical Letters (TLs), which were approved by WADA’s Executive Committee on 20 May 2021.
Under the International Standard for Laboratories (ISL), WADA’s TDs are issued to provide direction to WADA-accredited Laboratories, WADA-approved Laboratories and other stakeholders on specific technical or procedural issues. As part of WADA’s mandate to enhance anti-doping activities under the World Anti-Doping Code, TDs undergo periodic revisions to address scientific and technological advances in the performance of anti-doping tests and the reporting of test results, as well as to reflect feedback received from WADA-accredited Laboratories and other WADA stakeholders.
The revised TDs, along with their Summaries of Modifications, are listed below and are available and indexed on WADA’s website:
1. TD2021BAR – Analytical Requirements for the Hematological Module of the Athlete Biological Passport, along with the Summary of Modifications. In this revised version of the TD2021BAR, in Article 6.1, the reference to International Standard for Testing and Investigations (ISTI) Annex K, Article K.2.4 was replaced by ISTI Annex I, Article I.2.7.
2. TD2021EPO – Harmonization of Analysis and Reporting of Erythropoietin (EPO) and other Erythropoietin-Receptor Agonists (ERAs) by Polyacrylamide Gel Electrophoretic (PAGE) Analytical Methods, along with the Summary of Modifications. In this revised version of the TD2021EPO, the implementation date of the TD was postponed to 1 September 2021. This modification, which was requested by the WADA EPO Working Group, was triggered by the difficulties faced by certain laboratories in becoming compliant with the new requirements of the TD2021EPO under the existing COVID-19 pandemic restrictions.
3. TD2021IRMS – Detection of Synthetic Forms of Prohibited Substances by GC/C/IRMS, along with the Summary of Modifications. In this revised version of the TD2021IRMS, the following points were modified:
4. TD2021NA – Harmonization of Analysis and Reporting of 19-Norsteroids Related to Nandrolone, along with the Summary of Modifications. In this revised version of the TD, the unnecessary requirement to inject a blank urine sample before the sample under confirmation was removed from Article 3.2.3. It is considered that the potential of any contamination shall be addressed by the laboratory during method validation, and that the use of negative quality control (NQC) and positive quality control (PQC) samples is sufficient to monitor any issues during routine analysis.
5. TD2021EAAS – Measuring and Reporting of Endogenous Anabolic Androgenic Steroid (EAAS) Markers of the Urinary Steroid Profile, along with the Summary of Modifications. In this revised version of the TD, the misquotation of some article numbers, which erroneously referenced articles that no longer exist in the TD2021IRMS, was corrected in Articles 3.3.1 and 3.3.2. Therefore, those specific TDIRMS article numbers have been removed and replaced by a general reference to the TDIRMS. In addition, it was clarified in Article 3.3.2 that the Laboratory shall also report the measured specific gravity of the “B” Sample.
All WADA-accredited Laboratories are required to implement these TDs in their procedures by the following deadlines (WADA-approved Laboratories are only expected to implement TD2021BAR):
1 June 2021:
1 September 2021:
Under the ISL, WADA’s TLs are issued in letter format on an ad-hoc basis in order to provide direction to the WADA-accredited and WADA-approved Laboratories and other stakeholders on particular issues related to the analysis, interpretation and reporting of results for specific Prohibited Substance(s) and/or Prohibited Method(s) or to the application of specific laboratory procedures.
• TL23 – Minimum Reporting Level for Certain Substances known to be Potential Meat Contaminants. This new TL includes clarification regarding the reporting and results management of findings for certain substances (clenbuterol, ractopamine, zeranol and zilpaterol) which may be used as growth promoters for livestock in some countries and therefore may be associated with findings resulting from the consumption of contaminated meat.
• TL24 – Minimum Reporting Level for Certain Diuretics that are known Contaminants of Pharmaceutical Products. This new TL includes clarification regarding the reporting and results management of findings for certain diuretics (acetazolamide, bumetanide, furosemide, hydrochlorothiazide, torsemide and triamterene) which are known to be found as contaminants of some pharmaceutical products.
All WADA-accredited and WADA-approved Laboratories are required to implement these new TLs in their procedures by 1 June 2021.
• This media release was published by the World Anti-Doping Agency (WADA) on 31 May 2021. Click here for the original.
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