28th September 2021

Italy: two sanctioned & one suspended after positive test for three substances

An Italian weightlifter and a track and field athlete have been sanctioned for anti-doping rule violations, while a cyclist has been provisionally suspended for an adverse analytical finding (AAF – or ‘positive test’) involving three substances, Italy’s anti-doping agency (NADO Italia) announced. Pier Luigi Pasini, who also competes in CrossFit and who finished 136th in the 88kg bench press this year, was sanctioned with a four year ban from 21 September. 

Ultrarunner Luca Manfredi was provisionally suspended on 27 July after a sample given at the Lavarado Ultra Trail on 26 June returned an AAF for a metabolite of triamcinolone acetonide. He has been sanctioned with a one year ban ending on 26 July 2022, and his Lavarado Ultra Trail result has been cancelled. 

Mountain biker Emanuele Broccolini has been provisionally suspended after returning an AAF for ostarine, GW1516 and RAD140 at the Straccabike 2021 on 5 September. GW1516 is a peroxisome proliferator-activated receptor (PPARδ) nuclear hormone receptor agonist that was developed by Ligand Pharmaceuticals and GlaxoSmithKline in the 1990s. It was abandoned as a developmental drug for metabolic and cardiovascular diseases because although a 2007 study found that it improved the physical performance of mice, animal tests found that it caused cancer to develop.

RAD140 is a selective androgen receptor modulator (SARM) developed by Radius Health for use in androgen replacement therapy and licensed for human use via Ellipses Pharmaceuticals in 2020. A 2010 Study found that it increased lean muscle mass when used by primates, by targeting androgen receptors in skeletal tissue.

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